HLA-C and neoplasm: Cancers possess a broad repetoire of means to evade the host defense, including mimicking self, down-regulation of MHC molecules and interference with antigen presentation, production of factors that are lethal to or paralyzing T cells and lastly recruitment of so-called regulatory immune cells (tumor-infiltrating leukocytes, myeloid-derived suppressor cells (MDSCs) and regulatory T cells) that control effector immune cell functions and ultimately promote the evasion of immune surveillance [39].