As others have reported [12,20,23], we found that treatment of HCT-116 tumor-bearing mice with GLV-1h68 up-regulated (from at least 4-fold to 230-fold) pro-inflammatory cytokines and chemokines, like GPC-2, KC/GRO, IFN-γ, IP-10, IL-6, M-CSF-1 ,MIP-1 beta, MIP-2 and MIP-3, MCP-1, MCP-3, MCP-5, RANTES and TNF-γ. Here, GPC2 is linked to neoplasm.