In addition, the analysis identified KLHL6 (a target of CN gains in 23% of cases and mutations in 8%), a gene involved in BCR signaling and germinal center formation in mice [30], IL31 (CN gains in 18% of cases and mutations in 3%), a gene involved in the activation of JAK/STAT, PI3K/AKT and MAPK signaling [31], and LRP1 (gained in 24% of cases and mutated in 3%), a gene promoting cancer cell invasion [32]. This evidence concerns the gene AKT1 and cancer.