CD274 and neoplasm: In addition, the method identified the PDCD1LG2/CD274 region [16,17], 17p13.3, a region that has been implicated as a tumor-suppressor region in medulloblastoma, where it is deleted in 40% of cases [18] and ARID1B, a member of the SWI/SNF chromatin remodeler complex implicated in differentiation and development [19].