In a recent study [48], CR in fact attenuated experimental autoimmune encephalomyelitis (EAE, a rodent model for multiple sclerosis) in mice, an autoimmune disease driven by antigen-specific Th1 and Th17 response and mitigated by Treg cells; however, CD4+ T cell subsets were not examined in that study. Here, CD4 is linked to autoimmune disease.