In fact, CD1d deficiency exacerbates nephritis and reduces survival in the hydrocarbon oil-induced and BWF1 models of lupus and dermatitis in MRL-lpr mice [8,24,42], although it has no effect on nephritis in MRL-lpr mice, or on survival in BXSB.Yaa mice [16,36,42]. This evidence concerns the gene CD1D and skin disorder.