Our study’s findings of the significant anti-proliferative effects of miR-497 further corroborate a tumor suppressive role for miR-497 in neuroblastoma, through the direct targeting of WEE1. Considering the significant increase in apoptosis due to WEE1 knock-down alone in MNA cell lines, or WEE1 knockdown in combination with CDDP in both MNA and non-MNA cell lines, further investigation of WEE1 as a potentially important therapeutic target in neuroblastoma is warranted. Here, WEE1 is linked to neuroblastoma.