WEE1 and neuroblastoma: We demonstrate that miR-497 over-expression results in significantly decreased cell viability through increased apoptotic rates in MNA neuroblastoma cells, in part, through the direct targeting of the 3′UTR of WEE1. Furthermore, we observe that higher than median WEE1 levels are significantly associated with poor EFS and OS in neuroblastoma and that siRNA knockdown of WEE1 in MNA neuroblastoma cell lines results in significant and profound levels of apoptosis, supporting an oncogenic role of WEE1 in neuroblastoma.