CNR2 and fibrosis: We have found that whereas the CB2 Q63R variant was not associated with steatosis or fibrosis, it was associated with the severity of the inflammation (P = 0.002), and the presence of NASH (P = 0.02), suggesting a critical role for the CB2 Q63R variant in modulating the hepatic inflammation state in obese children, and in the consequent increased predisposition of these patients to develop liver damage.