Considering the extensive evidence that glioma cells produce high levels of VEGF, and Mifepristone decreases the expression of VEGF in prostate cancer cells [16], breast cancer [32] and gastric cancer cells [33]; we also investigated the possible participation of Mifepristone in the inhibition of VEGF expression in glioma xenografts. The gene discussed is VEGFA; the disease is central nervous system cancer.