Recently it was reported that vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), cyclin D1 and progesterone receptor (PR) expression levels are elevated in patients with high–grade astrocytomas and progesterone regulates astrocytomas growth through its interaction with progesterone receptor [14]. The gene discussed is PGR; the disease is astrocytoma (excluding glioblastoma).