However, in a recent study, administration of recombinant human NRG-1 (rhNRG-1) to STZ-induced diabetic cardiomyopathy rats rescued the depressed cardiac function [12] suggesting that derangements in NRG-1/ErbB may play a causal role in the decreased cardiac function brought about by DM. The gene discussed is NRG1; the disease is diabetic cardiomyopathy.