Similarly in a nested case control study of 592 lung cancer patients and 670 controls pre-diagnostic elevated C-reactive protein was found to be associated with increased risk of lung cancer development (odds ratio [OR], 1.98; 95% CI, 1.35 to 2.89; P-trend < .001 for fourth quartile [Q4, ≥5.6 mg/L] v Q1 [< 1.0 mg/L]) [14]. The gene discussed is CRP; the disease is lung cancer.