In an another study of mostly stage III and few stage IV NSCLC patients elevated CRP at the time of diagnosis was associated with increased weight loss (P = 0.004), reduced albumin (P = 0.001), reduced performance status (p = 0.06), increased fatigue (P = 0.01) and reduced survival (HR 1.93,95% CI 1.41-2.6, P <0.001) [17]. This evidence concerns the gene ALB and non-small cell lung carcinoma.