TP53 and glioblastoma: The kinetics of intracellular ceramide production was assessed after exposure of the four HNSCC or glioblastoma cells, displaying different radiosensitivity and p53-status[11,15] (Table 1), to 10Gy irradiation with photons (low LET) or with 2 high LET carbon ions (33.4 or 184 keV/μm).