The link between E-Cadherin and HIF-1α/glycolysis is novel and suggests that E-Cadherin is a bona-fide signaling molecule that indirectly regulates HIF-1α which ultimately mediates not only metabolic responses of tumor cells (ie, glycolysis) but also regulates in vivo growth in part due to impacting responses in the microenvironment such as interactions with vascular endothelium during tumor vascularization and tumor angiogenesis. Here, CDH1 is linked to neoplasm.