While recent studies have focused on the loss of E-Cadherin as part of the process of EMT, other studies suggest that the maintenance of E-Cadherin is likely to function as an oncogene depending of the cellular context, similar to reports of the dichotomous tumor-suppressing or tumor-promoting function of Transforming growth factor beta (TGFβ) [28]. This evidence concerns the gene TGFB1 and neoplasm.