Interestingly, overt EMT in the PC3 prostate cancer and the TSU-Pr1 bladder cell lines was demonstrated to lead to reduced tumor-initiating or CSC potential compared to their epithelial sublines [6, 35], which is consistent with our in vivo results of reduced tumor-initiating potential in the M-SUM149 clones, Mary-X-shEcad and 4T1-shECad cells. Here, TMEM37 is linked to prostate cancer.