We recently discovered that FTS reverses the epithelial-mesenchymal (EMT)-like transition phenotype of NF1-deficient MPNST cells by perturbing the signaling of bone morphogenetic protein (BMP)4 and transforming growth factor (TGF)-β1 to SMAD-dependent and ERK-dependent pathways, inhibiting motility, spreading and gelatinase secretion, and alternating gene expression [45]. Here, AKTIP is linked to malignant peripheral nerve sheath tumor.