Therefore, in order to predict the possible targets and reasons for some of the traceable ineffectiveness of these metal-based complexes, ten protein targets which are recombinant human albumin (rHA), thymidylate synthase (TS), ribonucleotide reductases (RNR), histone deacetylase (HDAC7), cathepsin B (CatB), topoisomerase II (Top II), thioredoxin reductase (TrxR), BRAF kinase and histone protein in nucleosome core particle (NCP) are used in this project either due to their reported roles in cancer growth or as transport agents that affect drug phamarcokinetic properties (e.g., rHA). The gene discussed is TYMS; the disease is cancer.