Additionally, profiling of dysregulated miRNA expression in the CD133+ subpopulation of ovarian cancer cell line indicated that several miRNAs are upregulated, including miR-205, miR-146a, miR-200a and miR-200b, whereas miR-1202 and miR-1181 are downregulated, which indicates that miRNAs can modulate the properties of ovarian CSC/TICs [80]. This evidence concerns the gene PROM1 and ovarian carcinoma.