H2AX and neoplasm: Specifically, DNA damage induced by the inhibition of endoglin was associated with the inhibition of several DNA repair genes, such as BARD1, H2AFX, NBN, NTHL1, and SIRT1. As this membrane protein is highly expressed in ovarian chemoresistant CSC/TICs and tumor-associated endothelial cells, inhibiting endoglin might increase platinum sensitivity and be effective for the treatment of ovarian cancer by targeting both tumor angiogenesis and ovarian CSC/TICs.