Thus, the stem cell marker nanog was found expressed in ovarian cancer cell lines and patients with advanced tumor stages, resistant to chemotherapy [78] Further, nanog was found to be an independent prognostic factor for disease survival of patients, increasing invasiveness and metastatic potential by direct suppression of Cdh1, caveolin-1, FOXO1, FOXO3a, FOXJ1 and FOXB1 [79]. Here, CDH1 is linked to ovarian carcinoma.