Additionally, germline mutations at the paralogous position have been identified in FGFR3 associated with three different skeletal syndromes – TDII (p.K650E), severe achondroplasia with developmental delay and aconthosis nigricans (SADDAN) syndrome, and TDI (both due to p.K650M) [37], [38], [39]. This evidence concerns the gene FGFR3 and achondroplasia.