Additionally, germline mutations at the paralogous position have been identified in FGFR3 associated with three different skeletal syndromes – TDII (p.K650E), severe achondroplasia with developmental delay and aconthosis nigricans (SADDAN) syndrome, and TDI (both due to p.K650M) [37], [38], [39]. Here, FGFR3 is linked to Global developmental delay.