Our identification, in an exploratory genetic analysis aimed at investigating the relevance of our mouse model in human POAG, of a variant (rs11722059) in the GUCY1A3/GUCY1B3 locus significantly associated with a subpopulation of POAG patients characterized by paracentral scotomas, is a step towards understanding the contribution of sGC to the etiology of this important subtype of POAG. Here, SGCB is linked to open-angle glaucoma.