In this study, we employed a meta-analysis to provide the assessment of the association between IGFBP3 A-202C and Gly32Ala polymorphisms and colorectal cancer risk by critically reviewing 5 studies of the A-202C polymorphism (a total of 3157 cases and 6027 controls) and 4 studies of the Gly32Ala polymorphism (a total of 1711 cases and 2995 controls). The gene discussed is IGFBP3; the disease is colorectal cancer.