However, it is hard to explore the association between IGFBP3 SNPs and colorectal cancer because there are only 3 papers to investigate this issue before 2009, another two articles(Xiang et al [16] and Feik at al [17]) exploring this issue were published in 2009 and 2010, however, these results are contrary than conclusive, so we think it is meaningful to estimate the effect of genotypes of IGFBP3 on risk for colorectal cancer. The gene discussed is IGFBP3; the disease is colorectal cancer.