A few studies have confirmed that IGFBP-3 levels are influenced by the -A202C IGFBP3 polymorphism [11], [26], and this polymorphism could influence responsiveness to growth inhibitors whose action involves up-regulation of IGFBP3 and the efficacy of various agents proposed for cancer chemoprevention [11]. The gene discussed is IGFBP3; the disease is cancer.