Interestingly, DAMP molecules High-Mobility Group Protein B1 and S100A8/9 have the ability to bind heparin sulfate and heparin sulfate proteoglycans, which are known to be coligands involved in NCR dependent recognition of tumor cells, resulting in secretion of IFN-γ but not cytotoxicity [33]–[35]. This evidence concerns the gene HMGB1 and neoplasm.