Secondly, we sought SPINK1 expression in additional macroregenerative nodules (MRN), low grade dysplastic nodules (LGN) and high grade dysplastic nodules (HGN) from 5 patients who had undergone liver transplantation, giving a total of 8 MRN, 7 LGN and 3 HGN. This evidence concerns the gene SPINK1 and dysplasia.