SPINK1 is the HUGO Gene Nomenclature Committee approved name for the gene originally identified as a trypsin inhibitor in bovine pancreas [22] and first described as a candidate tumour marker in ovarian cancer [23], [24], SPINK1 has historically been called tumor-associated trypsin inhibitor (TATI) and pancreatic secretory trypsin inhibitor (PSTI)). Here, SPINK1 is linked to neoplasm.