In conclusion, by systematically integrating 10 well-characterized association studies for Han Chinese, with 1425 T2DM patients and 1116 healthy subjects, we found that TNF-α −308G>A (rs1800629) polymorphism were statistically significantly associated with T2DM in Han Chinese population, suggesting that A allele at this locus increases the risk for the development of T2DM in this population. Here, TNF is linked to type 2 diabetes mellitus.