GSK3B and colorectal cancer: Figure 3 depicts the KEGG colorectal cancer pathway using KEGG Mapper and shows that MA downregulated glycogen synthase kinase 3β (Gsk3b), a protein involved in Wnt/β-catenin signaling that is affected in ApcMin/+ mice. Interestingly, MA also inhibited Cyclin D (Ccnd1) (Figure 3), a gene expressed after the transcriptional activation of β-catenin.