To investigate whether the reciprocal regulation of cMyc and miR-125b-5p is also seen in vivo in CTCL we analyzed 17 skin lesions from patients with mycosis fungoides (T2, n = 11; T3, n = 6) for cMyc and miR-125b-5p by immunohistochemistry (IHC) and in situ hybridization (ISH), respectively. The gene discussed is MYC; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.