CDH17 and early-onset autosomal dominant Alzheimer disease: These included signaling pathways regulating pyrimidine metabolism, p38MAPK pathway, synaptic vesicle trafficking, Alzheimer’s disease-amyloid secretase, axon guidance mediated by semaphorins, cadherin signaling pathways, and the integrin signaling pathway which has previously been implicated in CSPG signaling [24].