C3 and infection: Compilation of the top 10 up- and bottom 10 down-regulated DE genes in the system each at 6, 12, 16 and 24 hours post infection revealed a pool of 18 genes: TNF, RRAD, HSPA1B, MAP3K8, TNFSF13, HSPA1A, HMOX1, GJA1, CCRL1, C3, HBEGF, CCL3L1, HSPA6, HLA-DOA, HLA-DMB, RAMP2, CD14 and CTSZ as the most actively down-regulated genes, while a pool of 20 genes: RAB7B, CD34, IL3RA, HLA-A, ACVR1, CD24, VEGFA, RAB11A, GPX1, VDAC3, PSME2, SLC16A3, MMP9, LGALS9, PLA2G2D, CCL2, CCL8, TRAPPC4, IDO1 and CXCL6 as the most actively up-regulated genes, respectively.