Studies in autoimmune diseases [78] showed that “interferogenic” immune complexes of IgG and self-nucleic acids internalized via FcγRIIA (CD32A) to endosomes by plasmacytoid DCs (pDCs) where they engage Toll Like receptors (TLRs) to activate production of inflammatory cytokines and type I interferons [79]. Here, FCGR2A is linked to autoimmune disease.