CCND1 and familial pancreatic carcinoma: Furthermore, we examined the expression of Six1 and cyclin D1 in three other independent pancreatic cancer microarray datasets and all of them showed a significant correlation between the two (GSE15471: r: 0.477, P = 0.0021; GSE32676: r: 0.372, P = 0.036; and GSE28735: r: 0.767, P<0.0001; Figure 4C).