Use of acetylcholinesterase inhibitors is associated with higher rates of syncope, bradycardia, and hip fractures in older adults with dementia, [35] although a recent case-control study of 2258 AD patients (and 80 hip fractures) found an association between acetylcholinesterase inhibitor use and decreased risk of hip fracture [36]. The gene discussed is ACHE; the disease is Alzheimer disease.