This could lead to an enhancement on gp120 binding and HIV uptake and to be further enhanced by the interaction between collectins and the SP-A and SP-D binding molecule DMBT1gp-340[58], [59], which is also present on mucosal surfaces and has also has been shown to bind to HIV and gp120, inhibit infectivity in in vitro in cells culture assay and facilitate trans-infection to T-cells [60]–[63], or a number of other cellular candidate receptors for collectins, such as SIRPalpha and calreticulin/CD91 [10]. This evidence concerns the gene SIRPA and infection.