CD4 and uveitis: Similar to the PBMCs, the production of IL-22 following stimulation of purified CD4+T cells was significantly higher in patients with BD disease with active uveitis (2520±607 pg/ml) than in patients with BD disease with inactive uveitis (1395±312 pg/ml, p<0.001) or normal controls (1488±358 pg/ml, p<0.001) (Fig. 1B).