Moreover, tumor angiogenesis indicated by mRNA expression of VEGF-A, PDGF-A, and IL-6 in the lung detected by real-time PCR using the human-specific primers was still much less in the IFN-α withdrawal group than in the continuous group (0.03±0.04 versus 2.88±0.30, P = 0.025; 0.04±0.02 versus 3.40±0.22, P = 0.004; 0.02±0.02 versus 0.08±0.02, P = 0.0007 for VEGF-A, PDGF-A, and IL-6 in IFN-α withdrawal and continuous groups, expressed in 2−ΔCT, respectively). This evidence concerns the gene IL6 and neoplasm.