As shown in Figure 6E, intravenous injection of 4T1-L10 cells resulted in an approximately 2-fold higher number of tumor nodules in the lung of WT (left panel) and MCP-1−/− mice (right panel), suggesting that tumor cell-derived MCP-1 may contribute to the lung metastasis by supporting their survival and seeding in the lung once tumor cells invade blood vessels. This evidence concerns the gene CCL2 and neoplasm.