The role of TNFAIP3 in antiapoptotic function [22] and the association of its' mutations with Crohn's disease, rheumatoid arthritis, systemic lupus erythematous, psoriasis, type 1 diabetes [23] could explain the association of vitamin D sufficiency in the prevention of chronic inflammation and autoimmune diseases. This evidence concerns the gene TNFAIP3 and autoimmune disease.