In this regard, it is attempting to speculate that the interaction of GAPDH with Mst1 may cause a conformational change of Mst1, thus affecting the formation of the Mst1/Hippo signaling complex with other proteins, such as Rassf1, hWW45, and Lats, which have recently been shown to play essential roles in the regulation of cardiomyocyte apoptosis and heart failure [39], [40]. The gene discussed is SAV1; the disease is heart failure.