We previously showed, in several different animal cancer models (rat C6 glioma [15], murine teratocarcinoma [16], transgenic spontaneous hepatoma [17], commentary rat/LFCI2A-hepatocarcinoma [18]), and, in human glioblastoma cell lines [19], an up-regulation in expression of MHC class 1 following down-regulation in cellular IGF-1 by transfection with the pAnti IGF-1 (an IGF-1 antisense RNA expression vector) [19]–[21]. Here, IGF1 is linked to cancer.