Recently, results from the Joslin Kidney Study demonstrated that among several inflammatory markers measured, increased concentrations of circulating Tumor Necrosis Factor Receptor (TNFR) 1 and TNFR2 emerged as very strong predictors of diabetic nephropathy progression to chronic kidney disease (CKD) stage 3 or ESRD [6], [7]. The gene discussed is TNFRSF1B; the disease is chronic kidney disease.