HAVCR2 and hepatocellular carcinoma: In TILs isolated from HCC tissues, Tim-3+ CD4 T cells produced significantly less IFN-γ and IL-2 than the Tim-3− CD4 T cells (22.1±6.4% vs. 43.9±6.9%, P<0.01 for IFN-γ; 7.8±2.8% vs. 41.7±3.7%, P<0.001 for IL-2, respectively; Figure 2A and 2B).