HAVCR2 and hepatocellular carcinoma: The frequency of Tim-3+ CD4 T cells and mean fluorescence intensity (MFI) for Tim-3 were significantly higher in TILs than the NILs of the same HCC patients (32.9±2.8% vs. 16.5±1.9% for frequency; 100.7±11.7 vs. 67.1±6.7 for MFI, respectively; both P<0.001, Figure 1B and 1C).