Latest reports on recurrent mutations in genes encoding several epigenetic regulators such as SWI/SNF complex gene PBRM1[8], methyltransferases SETD2 and MLL2, demethylases UTX (KDM6A) and JARID1C (KDM5C) [6] suggest possible implications of epigenetic variation in ccRCC. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.