The 50 genes overexpressed in the process of ccRCC growth with the highest fold change (logFC >2) included NADH dehydrogenase - NDUFA4L2, angiopoietin (ANGPTL4), PNCK kinase, carbonic anhydrase IX (CA9), neuronal pentraxin II (NTPX2), nicotinamide N-methyltransferase (NNMT), genes encoding glycoproteins VWF and STC2, insulin-like growth factor binding protein 3 (IGFBP3), solute carrier family genes (SLC16A3 and SLC6A3), fatty acid binding protein 7 (FABP7), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) and transforming growth factor (TGFBI). The gene discussed is VWF; the disease is nonpapillary renal cell carcinoma.