In our study several immune response and inflammatory genes were found to be upregulated in ccRCC, including IL2RA, IL2RB, IL7R, IL10RB as well as tumour necrosis factor family genes TNFAIP3, TNFAIP6, TNFAIP8, TNFRSF4. This evidence concerns the gene TNFAIP8 and nonpapillary renal cell carcinoma.