Other pathways known to be associated with ccRCC have been identified including gene sets linked to hypoxia (HIF pathway), angiogenesis (VEGF pathway) as well as immune and inflammatory signalling (INFLAM, TOLL, TH1TH2, NFKB, NKCELLS, TCR, DC, TNFR1, TNFR2, CYTOKINE) pathways. This evidence concerns the gene TNFRSF1A and nonpapillary renal cell carcinoma.