Latest reports on recurrent mutations in genes encoding several epigenetic regulators such as SWI/SNF complex gene PBRM1[8], methyltransferases SETD2 and MLL2, demethylases UTX (KDM6A) and JARID1C (KDM5C) [6] suggest possible implications of epigenetic variation in ccRCC. Here, MBD2 is linked to nonpapillary renal cell carcinoma.