In our study several immune response and inflammatory genes were found to be upregulated in ccRCC, including IL2RA, IL2RB, IL7R, IL10RB as well as tumour necrosis factor family genes TNFAIP3, TNFAIP6, TNFAIP8, TNFRSF4. The gene discussed is TNFAIP6; the disease is nonpapillary renal cell carcinoma.