ESR1 and neoplasm: Univariate analyses (Table 1) showed that pathological tumor size (p = 0.03), histological type (p = 0.03), lympho-vascular invasion (p = 0.01), histological grade (p = 0.00002), immunophenotypic subtypes (ER+ HER2− and ER−; p = 0.0006), and Ki67 rate (p<10e−6) were associated with an increased rate of distant metastases.