MSH2 and Lynch syndrome: Moreover, we found that the most common pathogenic deleterious variants in Lynch syndrome were hMSH2 Intron5 c.942+3A>T, and hMLH1 Intron9 c.790+1G>A, with a mutational consequence of deletion of exon5 in hMSH2 and a deletion of exon9–10 in hMLH1.