MSH6 and endometrial cancer: Not only hMLH1 and hMSH2 gene, we remained concerned about the prevalence of these mutations of other MMR genes, in particular hMSH6 or hPMS2. In 2009, a systematic review was conducted and a meta-analysis was undertaken to determine the frequency of hMSH6 mutation in colorectal and endometrial cancers by our academic team [136].