PML and neoplasm: Several lines of evidence underscore the role of PML in tumor suppression (Wang et al., 1998a; Rego et al., 2001; Scaglioni et al., 2006; Trotman et al., 2006), senescence, and apoptosis (Wang et al., 1998b; Ferbeyre et al., 2000; Guo et al., 2000; Pearson et al., 2000; Bischof et al., 2002; Scaglioni et al., 2012).