Moreover, a CX-4945, a specific pharmacologic inhibitor of CK2, is being tested in early clinical trials in cancer patients: these drugs could be instrumental in restoring PML in cancer cells (Hanif et al., 2010; Siddiqui-Jain et al., 2010; Ferguson et al., 2011; Sarno et al., 2011; Cozza et al., 2012). This evidence concerns the gene PML and cancer.