In healthy women, this manipulation has not been considered to have the potential to increase the risk of breast cancer, gynecologic cancers, etc. [19–21], and pregnancy after estrogen receptor (ER)-positive breast cancer does not seem to increase the risk of recurrence [22]; however, the influence of follicle stimulation on the prognosis of ER-positive breast cancer patients is unclear [23, 24]. The gene discussed is ESR1; the disease is female reproductive organ cancer.