The results of a phase II study of IMC-A12, with or without cetuximab, in patients with refractory metastatic colorectal cancer documented that IMC-A12 alone, or in combination with cetuximab, was insufficient to warrant additional study in patients with colorectal cancer refractory to EGFR inhibitors (Reidy et al., 2010). Here, EGFR is linked to colorectal cancer.