CTSB and ovarian neoplasm: ORF1 of CRMaV encodes a protein with a relative molecular mass (Mr) of 230 kDa containing the conserved domains for viral methyltransferase (Met), helicase (Hel) and RNA-dependent RNA polymerase (RdRp) associated with the replicases of plant viruses; a papain-like cysteine protease (P-Pro) that processes the replicase polyprotein; an AlkB homologue; and an ovarian tumor (OTU)-like cysteine protease.