As RAGE is mainly expressed in PAH‐PASMCs, we focused our research on PASMCs and provide evidence rather than in primary culture (<6 passages) of human PASMCs from healthy donors, and PAH patients' RAGE mRNA and protein expression was ≥5‐fold greater in PAH‐PASMCs than in control cells (n=3 to 5 cell lines, P<0.01; Figure 1A). The gene discussed is AGER; the disease is pulmonary arterial hypertension.