The present study aimed to elucidate the role of RAGE in PAH etiology because this receptor is widely overexpressed in PAH patients' lungs, is implicated in vascular remodeling, and could explain STAT3 activation as well as BMPR2 and PPARγ downregulation, known to be implicated in PAH pathobiology. The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.