AGER and pulmonary arterial hypertension: To study the effect of RAGE on PASMC proliferation and apoptosis in vitro, we developed a model in which cultured human PAH‐PASMCs were exposed to 10% FBS to promote proliferation34 or 0.1% FBS to promote apoptosis,34 followed by ectopic delivery of RAGE siRNA (20 nmol/L for 48 hours).