The increased activation of STAT3 was mediated through an interaction with RAGE, as RAGE siRNA decreased it in PAH‐PASMCs (Figure 2), and RAGE activation (S100A4) promoted it in healthy PASMCs (n=3 to 5 cell lines, P<0.05, Figure 2). The gene discussed is S100A4; the disease is pulmonary arterial hypertension.