AGER and pulmonary arterial hypertension: RAGE siRNA‐treated rats demonstrated a decrease >25 mm Hg in PA pressure and decreased RV hypertrophy, demonstrating the beneficial effect of RAGE inhibition in PAH not only on pressure (control rats have mPAP ≈15 mm Hg, PAH rats have mPAP >40 mm Hg, and with RAGE inhibition, mPAP decreases to 20 and 28 mm Hg, respectively, in MCT and Sugen models), but also on RV condition (35% decrease in RV hypertrophy, n=8 rats per group, P<0.001; Figure 5C).