The activity of STAT3 (increased P‐STAT3/STAT3 ratio and P‐STAT3 nuclear translocation) was increased in PAH‐PASMCs, whereas both BMPR2 (immunoblot) and PPARγ were downregulated in PAH‐PASMCs (decreased expression—as seen from the lower percentage of green fluorescence and luciferase activity) (Figures 2 and 3). This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.