Other studies have found similarly higher levels of endothelial markers among individuals with prediabetes or diabetes compared with normal glucose levels.5,7 In a prospective analysis from the Nurses Health Study, Meigs and colleagues found that E‐selectin and ICAM‐1 were independently associated with incidence of diabetes.6 The biologic mechanisms determining endothelial protein secretion differ from the mechanisms for flow‐mediated dilation, which may account for the differing results for the impaired fasting glucose groups. The gene discussed is SELE; the disease is prediabetes syndrome.