One hypothesis is that higher CRP in the setting of an acute coronary syndrome reflects a greater burden of myocardial ischemia and tissue injury.14 Most studies of acute coronary syndromes, including MIRACL, support this concept, as subjects with higher troponins also have higher concentrations of CRP.11,16,22,27 Some earlier reports did not find a relationship between CRP and troponin, but this disparity may have been a result of the use of less sensitive troponin assays.5,28. The gene discussed is CRP; the disease is myocardial ischemia.