Several therapies that target the inflammatory response have been investigated in animal models of cerebral aneurysms.5 Promising results were reported with NF‐kB inhibitors,2 statins,29 matrix metalloproteinases inhibitors,25 free‐radical scavengers,30 and inhibitors of mast cell degranulation.27 Although these therapies appear to attenuate aneurysm formation and progression in experimental animals, it is not clear whether they protect against rupture of aneurysms. The gene discussed is NFKB1; the disease is aneurysm.