To examine in vivo the role of PlGF in Aldo‐induced atherosclerosis, we generated ApoE−/− mice that were also genetically deficient in PlGF and quantified plaque area under the same conditions that produced Aldo‐enhanced plaque burden in Figure 1B. ApoE−/−/PlGF−/− mice were treated with Aldo or vehicle and compared with ApoE−/−/PlGF‐intact littermates. Here, APOE is linked to atherosclerosis.