Previous studies showed that female ApoE−/−/PlGF−/− mice exhibit reduced plaque size compared with ApoE−/−/PlGF‐intact littermates after 10 weeks of a high‐fat diet.54 Here we observed no difference in atherosclerosis burden in vehicle‐treated male mice lacking PlGF after 4 weeks of high‐fat feeding. This evidence concerns the gene APOE and atherosclerosis.