To provide some indication as to whether the major cause of HK2 dissociation during ischemia was G‐6‐P or low pH, G‐6‐P content was determined in hearts at the end of ischemia in 4 groups of hearts showing a wide range of mtHK2—control, control high glucose, IP, and IP plus acetate (Figure 14A). The gene discussed is HK2; the disease is ischemia.